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Amyloid Protein Mediated Neurodegeneration in Alzheimers Disease Alzheimers Disease is a progressive, degenerative disease that affects the mentality. Individuals with AD analyze a progressive and specific loss of cognitive betroth resulting from the differentiation of the limbic system, association neocortex, and basal fore mastermind. It is also tended to(p) by the deposition of amyloid in plaques and cerebrovasculature, and the governance of neurofibrillary tangles in neurons. Alois Alzheimer, a German doctor, diagnosed this disease for the first time in 1907. At that time it was considered a r be disorder. Currently, this tragic brain disorder affects approximately four million people; It is the nigh common type of dementia and the fourth leading purge of death in the United States. Many studies have been do and are still being conducted to determine the exact vitrine of AD. The molecular and biological basis for the degeneration of neurons in AD is incompletely un derstood. However, the APP(Amyloid Precursor Protein) and its proteolytic fragments have been implicated to a great extent often than not and is the focus of most accepted studies. some(prenominal) lines of evidence have strengthened the amyloid hypothesis for Alzheimers Disease.

The first being the identification of point mutations with the APP gene in groups of patients afflicted with the familial forms of AD. Second, amyloid deposition temporally precedes the system of neurofibrillary changes. In addition, b-amyloid has been shown to be toxic to neurons. In Alzheimers Disease, b-Amyloid proteins derived from A PP are the main component of neuritic plaque! s. It is believed that errantly processed APP derivatives may induce physiologic processes that lead to neurodegeneration and plague formation. Many studies have success widey relate APP with AD. One study on transgenic mice with human APP717(associated with familial AD) displayed subcellular neurodegeneration standardized to those observed in AD, including dystrophic neurites,...If you want to get a all-inclusive essay, order it on our website: OrderCustomPaper.com

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